Sustained hypoxia enhances chondrocyte matrix synthesis.

@article{Coyle2009SustainedHE,
  title={Sustained hypoxia enhances chondrocyte matrix synthesis.},
  author={Christian H. Coyle and Nicholas John Izzo and Constance R. Chu},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2009},
  volume={27 6},
  pages={
          793-9
        }
}
Articular cartilage is an avascular tissue with chondrocytes in the deeper zones existing under conditions of sustained hypoxia. Using a hypoxic chamber to provide controlled hypoxia, this study was performed to determine whether sustained hypoxia enhances the production of cartilage matrix proteins. Freshly isolated primary bovine articular chondrocytes were encapsulated in three-dimensional alginate beads and maintained at 2% oxygen with media changes using media pre-equilibrated to 2% oxygen… CONTINUE READING
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SHOWING 1-10 OF 44 REFERENCES

Rediffer - entiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension

  • C Grimmer, N Balbus, U Lang
  • Osteoarthritis Cartilage
  • 2006

signal hypoxia to the nucleus . [ comment ]

  • D Pfander, B Swoboda, T Cramer
  • 2006

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