Sustained hypertension in the rat induced by chronic blockade of nitric oxide production.

@article{Johnson1992SustainedHI,
  title={Sustained hypertension in the rat induced by chronic blockade of nitric oxide production.},
  author={Rebecca Johnson and Ronald H. Freeman},
  journal={American journal of hypertension},
  year={1992},
  volume={5 12 Pt 1},
  pages={919-22}
}
It is well established that acute systemic blockage of L-arginine conversion to nitric oxide by NW-nitro-L-arginine methyl ester (L-NAME) and other substituted analogs of L-arginine produces vasoconstriction and elevates the blood pressure. The present study in rats reports that chronic L-NAME injections (185 mumol/L/kg body weight, intraperitoneally; every 12 h) for 4 days produces sustained arterial hypertension which is fully and rapidly reversed by acute administration of excess L-arginine… CONTINUE READING

From This Paper

Topics from this paper.
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…