Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

@article{Tsankova2006SustainedHC,
  title={Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action},
  author={Nadia M. Tsankova and Olivier Berton and William Renthal and Arvind Kumar and Rachel L Neve and Eric J. Nestler},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={519-525}
}
To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor (Bdnf) splice variant mRNAs (I–V) and their unique promoters in the hippocampus. Defeat stress induced lasting downregulation of Bdnf transcripts III and IV and robustly… Expand
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