Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.

@article{Hein2010SustainedHI,
  title={Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.},
  author={Amy M. Hein and Melissa R. Stasko and Sarah B. Matousek and Jonah Jacob Scott-McKean and Steven F. Maier and John A. Olschowka and Alberto C S Costa and M Kerry O'Banion},
  journal={Brain, behavior, and immunity},
  year={2010},
  volume={24 2},
  pages={243-53}
}
Neuroinflammatory conditions such as traumatic brain injury, aging, Alzheimer's disease, and Down syndrome are often associated with cognitive dysfunction. Much research has targeted inflammation as a causative mediator of these deficits, although the diverse cellular and molecular changes that accompany these disorders obscure the link between inflammation and impaired memory. Therefore, we used a transgenic mouse model with a dormant human IL-1beta excisional activation transgene to direct… CONTINUE READING
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