Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory.

@article{Moore2009SustainedEO,
  title={Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory.},
  author={Amy H. Moore and Ming Wu and Solomon S. Shaftel and Kaylan A Graham and M Kerry O'Banion},
  journal={Neuroscience},
  year={2009},
  volume={164 4},
  pages={1484-95}
}
Glial activation and neuroinflammation occur in neurodegenerative disease and brain injury, however their presence in normal brain aging suggests that chronic neuroinflammation may be a factor in age-related dementia. Few studies have investigated the impact of sustained elevation of hippocampal interleukin-1beta, a pro-inflammatory cytokine upregulated during aging and Alzheimer's disease, on cognition in mice. We utilized the IL-1beta(XAT) transgenic mouse to initiate bilateral hippocampal… CONTINUE READING
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