Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function

@article{BronsteinSitton2003SustainedET,
  title={Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function},
  author={Noem{\'i} Bronstein-Sitton and Leonor Cohen-Daniel and Ilan Vaknin and Anal{\'i}a V Ezernitchi and Benny Leshem and Amal Halabi and Yael Houri-Hadad and Eugenia Greenbaum and Zichria Zakay-Rones and Lior Shapira and Michal Baniyash},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={957-964}
}
T cell antigen receptor ζ chain down-regulation and impaired in vitro T cell function have been described in cancer and autoimmune and infectious diseases. However, the immunological basis for this phenomenon is unknown. Sustained exposure to antigen and chronic systemic inflammation, factors shared by the various pathologies, might account for this phenomenon. We developed an in vivo experimental system that mimics these conditions and show that sustained exposure of mice to bacterial antigens… CONTINUE READING

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