Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression.

@article{Gill2010SustainedEO,
  title={Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression.},
  author={J. M. Gill and David A. Luckenbaugh and Dennis C Charney and Meena Vythilingam},
  journal={Biological psychiatry},
  year={2010},
  volume={68 11},
  pages={999-1006}
}
BACKGROUND Elevated levels of proinflammatory cytokines, especially interleukin-6 (IL-6), can mediate the greater risk for cardiovascular disease in individuals with posttraumatic stress disorder (PTSD), particularly in those with comorbid major depressive disorder (MDD). However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD. METHODS Serum IL-6… CONTINUE READING

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