Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia.

Abstract

Cyclic nucleotides mediate transient as well as plastic cellular responses. The most ultimate response is cell death. In the present study, we propose that an increase of intracellular cyclic guanosine monophosphate (cGMP) for at least 1h promotes cell death in the murine microglial cell line, BV-2 cells, as well as in primary murine microglia. Cells were… (More)
DOI: 10.1016/j.brainresbull.2009.08.002

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