Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgery.

@article{Bloch2013SustainedEO,
  title={Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgery.},
  author={Susannah A A Bloch and Jen Y. Lee and Stephen John Wort and Michael Ian Polkey and Paul R Kemp and Mark J. D. Griffiths},
  journal={Critical care medicine},
  year={2013},
  volume={41 4},
  pages={982-9}
}
OBJECTIVES Acute muscle wasting in the critically ill is common and causes significant morbidity. In a novel human model of acute muscle wasting following cardiac surgery, known or potential circulating modulators of muscle mass--insulin-like growth factor-1, myostatin, and growth and differentiation factor-15--were measured over a week. It was hypothesized… CONTINUE READING