Sustained effect after lowering high-dose infliximab in patients with rheumatoid arthritis: a prospective dose titration study.

@article{Bemt2008SustainedEA,
  title={Sustained effect after lowering high-dose infliximab in patients with rheumatoid arthritis: a prospective dose titration study.},
  author={Bart J. F. van den Bemt and Alfons den Broeder and Gijs F Snijders and Yechiel Y A Hekster and Piet L. C. M. van Riel and Bart Benraad and Gerrit Jan J Wolbink and Frank H. J. van den Hoogen},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 12},
  pages={1697-701}
}
OBJECTIVES In clinical trials only a small subset of patients with rheumatoid arthritis (RA) benefits from higher than standard dose of infliximab (>3 mg/kg/8 weeks). However, dose escalation of infliximab is frequently applied in clinical practice. Individual adjustment of infliximab treatment based on actual disease activity, instead of subjective clinical judgement, could prevent possible unwarranted dose escalation. METHODS The infliximab dose of all patients with RA treated at our centre… CONTINUE READING

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