Sustained depolarizing shift of the GABA reversal potential by glutamate receptor activation in hippocampal neurons.

@article{Kitamura2008SustainedDS,
  title={Sustained depolarizing shift of the GABA reversal potential by glutamate receptor activation in hippocampal neurons.},
  author={Akihiko Kitamura and Hitoshi Ishibashi and Miho Watanabe and Yusuke Takatsuru and Malcolm S. Brodwick and Junichi Nabekura},
  journal={Neuroscience research},
  year={2008},
  volume={62 4},
  pages={270-7}
}
The inhibitory action of GABA is a consequence of a relatively hyperpolarized Cl(-) reversal potential (E(Cl)), which results from the activity of K(+)-Cl(-) cotransporter (KCC2). In this study we investigated the effects of glutamate and glutamatergic synaptic activity on E(Cl). In dissociated culture of mature hippocampal neurons, the application of glutamate caused positive E(Cl) shifts with two distinct temporal components. Following a large transient depolarizing state, the sustained… CONTINUE READING