Sustained delivery of vascular endothelial growth factor with alginate beads.

  title={Sustained delivery of vascular endothelial growth factor with alginate beads.},
  author={Frank X Gu and B G Brian G Amsden and Ronald J. Neufeld},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={96 3},
Therapeutic angiogenesis is the growth of blood vessels from a pre-existing vasculature for clinical applications such as treating myocardial and limb ischemia. Vascular endothelial growth factor (VEGF) is a potent signal transduction molecule that acts specifically on vascular endothelial cells. Encapsulation of VEGF in a polymer matrix not only protects protein against enzymatic degradation in the body, but also allows proteins to be released at a controllable rate into a localized area. In… CONTINUE READING
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