Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits.

@article{Leite2003SustainedDI,
  title={Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits.},
  author={Paulo Ferreira Leite and Alexandre Danilovic and Patr{\'i}cia Moriel and Katia Dantas and Stefan Marklund and Ana Paula Villela Dantas and Francisco R M Laurindo},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 12},
  pages={2197-202}
}
OBJECTIVE The redox pathophysiology of vascular repair is incompletely understood. We assessed the role of vascular superoxide dismutase (SOD) activity in oxidative/nitrative stress and caliber loss postinjury (PI). METHODS AND RESULTS Rabbits submitted to iliac artery balloon overdistension were followed for 14 days PI. Significant decrease in vascular SOD activity occurred at 7 and 14 days PI (by 45% and 34%, respectively, versus control, 96+/-1 U/mg, P<0.05). Separation in concanavalin-A… CONTINUE READING