Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?

@article{Khalil1988SustainedCO,
  title={Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?},
  author={Raouf Ali Khalil and Casey van Breemen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={244 2},
  pages={537-42}
}
We have investigated the relative contributions of Ca++ influx and C-kinase activation to the sustained contraction of smooth muscle of rabbit aorta. In physiological salt solution (PSS), the alpha adrenergic agonist, phenylephrine (PhE), induced a rapid initial contraction followed by a maintained tonic contraction whereas the C-kinase activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), caused only a slow tonic contractile response. Both PhE- and TPA-induced contractions were accompanied by… CONTINUE READING