Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study.

@article{Plowe2004SustainedCE,
  title={Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study.},
  author={Christopher V. Plowe and James G. Kublin and Fraction K. Dzinjalamala and Deborah S Kamwendo and Rabia A G Mukadam and Phillips Chimpeni and Malcolm Edward Molyneux and Terrie E. Taylor},
  journal={BMJ},
  year={2004},
  volume={328 7439},
  pages={545}
}
OBJECTIVE To measure the efficacy of sulfadoxine-pyrimethamine treatment of falciparum malaria in Malawi from 1998 to 2002, after a change from chloroquine to sulfadoxine-pyrimethamine as first line treatment in that country in 1993. DESIGN Prospective open label drug efficacy study. SETTING Health centre in large peri-urban township adjacent to Blantyre, Malawi. PARTICIPANTS People presenting to a health centre with uncomplicated Plasmodium falciparum malaria. MAIN OUTCOME MEASURES… CONTINUE READING

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