Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

@article{Condotta2013SustainedAI,
  title={Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.},
  author={Stephanie A. Condotta and Deepa Kumari Rai and Britnie R James and Thomas S Griffith and Vladimir P Badovinac},
  journal={Journal of immunology},
  year={2013},
  volume={190 5},
  pages={1991-2000}
}
Patients who survive severe sepsis often display compromised immune function with impairment in innate and adaptive immune responses. These septic patients are highly susceptible to "secondary" infections with intracellular pathogens that are usually controlled by CD8(+) T cells. It is not known when and if this observed immunoparalysis of CD8(+) T cell immunity recovers, and the long-term consequences of sepsis on the ability of naive CD8(+) T cells to respond to subsequent infections are… CONTINUE READING