Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects.

@article{Zhao2012SustainedAC,
  title={Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects.},
  author={Hong Liang Zhao and Chong Xue and Ji Liang Du and Min Ren and Shan Hong Xia and Yuan Guo Cheng and Zhi Min Liu},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={159 3},
  pages={346-52}
}
The unfavorable pharmacokinetics and low tumor specificity hampered the potential clinical utility of Onconase, a promising modality in anticancer treatment with unique targets and novel mechanism of action. In this study, a modular and multi-stage drug delivery system (DDS) that can break down organ (renal accumulation), cellular (cancer cell specific uptake) and sub-cellular (endosomal escape) level barriers encountered by Onconase during its long journey from injection site to the cytoplasm… CONTINUE READING