Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.

  title={Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.},
  author={Keqiang Ye and Jianhua Zhou and Jaren W. Landen and E. Morton Bradbury and Harish C. Joshi},
  journal={The Journal of biological chemistry},
  volume={276 50},
Mitotic arrest and subsequent apoptosis has been observed in many types of cells treated with anti-microtubule agents. However, the molecular mechanisms underlying the two events as well as their relationship are not well understood; on the contrary, there has been increasing evidence indicating that anti-microtubule agents might induce apoptosis via signaling pathways independent of mitosis. In this study, we found that apoptosis induced by noscapine, an anti-microtubule drug previously shown… CONTINUE READING


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