Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

@article{Lee2000SustainedAO,
  title={Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.},
  author={Sam W. Lee and L Fang and Makoto Igarashi and Toru 3 Ouchi and Kun Lu and Stuart A. Aaronson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 15},
  pages={
          8302-5
        }
}
The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence, or cause apoptosis depending on the cellular context. The mitogen-activated protein kinase (MAPK) cascade is known to play a crucial role in cell proliferation and differentiation. Moreover, the duration and intensity of MAPK activation can profoundly influence the biological response observed. We demonstrated that a sustained activation of MAPK cascade could be induced by wild… CONTINUE READING
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