Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.

@article{Young2018SustainedAO,
  title={Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.},
  author={Christopher N. J. Young and Natalia Chira and Justyna R{\'o}g and Rasha Al-khalidi and Magalie B{\'e}nard and Ludovic Galas and Philippe Chan and David Vaudry and Krzysztof Zablocki and Dariusz C G{\'o}recki},
  journal={Journal of molecular cell biology},
  year={2018},
  volume={10 3},
  pages={
          229-242
        }
}
P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular adenosine triphosphate (ATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational divergence and functional idiosyncrasy are ill-understood. We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent… CONTINUE READING

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