Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition

  title={Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition},
  author={Christopher N. J. Young and Natalia Chira and J. R{\'o}g and R. Al-khalidi and M. B{\'e}nard and L. Galas and P. Chan and D. Vaudry and K. Zabłocki and D. G{\'o}recki},
  journal={Journal of Molecular Cell Biology},
  • Christopher N. J. Young, Natalia Chira, +7 authors D. Górecki
  • Published 2018
  • Medicine
  • Journal of Molecular Cell Biology
  • P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular adenosine triphosphate (ATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational divergence and functional idiosyncrasy are ill-understood. We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent… CONTINUE READING
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