Sustained Release of Multiple Growth Factors from Injectable Polymeric System as a Novel Therapeutic Approach Towards Angiogenesis

@inproceedings{Sun2009SustainedRO,
  title={Sustained Release of Multiple Growth Factors from Injectable Polymeric System as a Novel Therapeutic Approach Towards Angiogenesis},
  author={Qinghua Sun and Eduardo A Silva and Aixia Wang and J. Christopher Fritton and David J Mooney and Mitchell B. Schaffler and P Michael Grossman and Sreekanth Rajagopalan},
  booktitle={Pharmaceutical Research},
  year={2009}
}
The aim was to investigate that a bio-degradable alginate and poly lactide-co-glycolide (PLG) system capable of delivering growth factors sequentially would be superior to single growth factor delivery in promoting neovascularization and improving perfusion. Three groups of apoE null mice underwent unilateral hindlimb ischemia surgery and received ischemic limb intramuscular injections of alginate (Blank), alginate containing VEGF165 (VEGF), or alginate containing VEGF165 combined with PLG… CONTINUE READING

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