Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress.

@article{Tay2014SustainedIA,
  title={Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress.},
  author={Kwang Hong Tay and Qi Luan and Amanda L Croft and Chen Chen Jiang and Lei Jin and Xu Dong Zhang and Hsin-Yi Tseng},
  journal={Cellular signalling},
  year={2014},
  volume={26 2},
  pages={287-94}
}
Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid attenuation of the IRE1α and ATF6 pathways but persistent activation of the PERK branch of the unfolded protein response (UPR) in cells. However, melanoma cells are largely resistant to ER stress-induced apoptosis, suggesting that the kinetics and durations of activation of… CONTINUE READING