Sustained Epigenetic Drug Delivery Depletes Cholesterol-Sphingomyelin Rafts from Resistant Breast Cancer Cells, Influencing Biophysical Characteristics of Membrane Lipids.

@article{Raghavan2015SustainedED,
  title={Sustained Epigenetic Drug Delivery Depletes Cholesterol-Sphingomyelin Rafts from Resistant Breast Cancer Cells, Influencing Biophysical Characteristics of Membrane Lipids.},
  author={Vijay Raghavan and Sivakumar Vijayaraghavalu and Chiranjeevi Peetla and Masayoshi Yamada and Megan V Morisada and Vinod Labhasetwar},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2015},
  volume={31 42},
  pages={11564-73}
}
Cell-membrane lipid composition can greatly influence biophysical properties of cell membranes, affecting various cellular functions. We previously showed that lipid synthesis becomes altered in the membranes of resistant breast cancer cells (MCF-7/ADR); they form a more rigid, hydrophobic lipid monolayer than do sensitive cell membranes (MCF-7). These changes in membrane lipids of resistant cells, attributed to epigenetic aberration, significantly affected drug transport and endocytic function… CONTINUE READING
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