Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia

@article{Miniaci2008SustainedCL,
  title={Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia},
  author={Maria Concetta Miniaci and Joung-Hun Kim and Sathyanarayanan V. Puthanveettil and Kausik Si and Huixiang Zhu and Eric R Kandel and Craig Bailey},
  journal={Neuron},
  year={2008},
  volume={59},
  pages={1024-1036}
}
The time course of the requirement for local protein synthesis in the stabilization of learning-related synaptic growth and the persistence of long-term memory was examined using Aplysia bifurcated sensory neuron-motor neuron cultures. We find that, following repeated pulses of serotonin (5-HT), the local perfusion of emetine, an inhibitor of protein synthesis, or a TAT-AS oligonucleotide directed against ApCPEB blocks long-term facilitation (LTF) at either 24 or 48 hr and leads to a selective… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

Activitydependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures

M. De Roo, P. Klauser, P. Mendez, L. Poglia, D. Muller
Cereb. Cortex • 2008
View 1 Excerpt

Synapse elimination accompanies functional plasticity in hippocampal neurons.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

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