Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis

@article{Glodek2003SustainedAO,
  title={Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis},
  author={Aleksandra M. Glodek and Marek J Honczarenko and Yi Q Le and James J Campbell and Leslie E Silberstein},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={461 - 473}
}
It is largely unknown how hematopoietic progenitors are positioned within specialized niches of the bone marrow microenvironment during development. Chemokines such as CXCL12, previously called stromal cell-derived factor 1, are known to activate cell integrins of circulating leukocytes resulting in transient adhesion before extravasation into tissues. However, this short-term effect does not explain the mechanism by which progenitor cells are retained for prolonged periods in the bone marrow… CONTINUE READING
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