Suspension cell culture and in vivo and in vitro chromosome constitution of mouse leukemia L1210.

@article{Moore1966SuspensionCC,
  title={Suspension cell culture and in vivo and in vitro chromosome constitution of mouse leukemia L1210.},
  author={George Edward Moore and Avery A. Sandberg and K Ulrich},
  journal={Journal of the National Cancer Institute},
  year={1966},
  volume={36 3},
  pages={405-13, 415-21}
}
An in vitro culture of mouse leukemia L1210 was established, along with conditions for optimal growth in suspension culture. L1210 showed a high requirement for folic acid in comparison with other cell lines in vitro. As few as 10 viable cells cultured in vitro killed DBA/2 mice. Cells from ascites showed a sharp mode of 40 chromosomes, with a minute marker chromosome and an extra-small, T-type (telocentric) chromosome. Cells cultured in vitro showed a mode of 40 or 41 chromosomes and contained… CONTINUE READING

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