Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury

@inproceedings{Aslami2010SuspendedAI,
  title={Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury},
  author={Hamid Aslami and Andr{\'e} P. Heinen and Joris J. T. H. Roelofs and Coert J Zuurbier and Marcus J. Schultz and Nicole P Juffermans},
  booktitle={Intensive Care Medicine},
  year={2010}
}
Acute lung injury is characterized by an exaggerated inflammatory response and a high metabolic demand. Mechanical ventilation can contribute to lung injury, resulting in ventilator-induced lung injury (VILI). A suspended-animation-like state induced by hydrogen sulfide (H2S) protects against hypoxia-induced organ injury. We hypothesized that suspended animation is protective in VILI by reducing metabolism and thereby CO2 production, allowing for a lower respiratory rate while maintaining… CONTINUE READING

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