Susceptible and protective human leukocyte antigen class II alleles and haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients.

@article{Motala2005SusceptibleAP,
  title={Susceptible and protective human leukocyte antigen class II alleles and haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients.},
  author={Ayesha A Motala and Marc Busson and Einas M. Al-Harbi and Manal A A Khuzam and Emtiaz M D Al-Omari and Mona R. Arekat and Wassim Youssef Almawi},
  journal={Clinical and diagnostic laboratory immunology},
  year={2005},
  volume={12 1},
  pages={
          213-7
        }
}
Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6+/-8.2 years; mean duration of diabetes, 7.7+/-7.1 years) who had a… CONTINUE READING