Susceptibility variants for male-pattern baldness on chromosome 20p11

  title={Susceptibility variants for male-pattern baldness on chromosome 20p11},
  author={Axel M Hillmer and Felix F. Brockschmidt and Sandra Hanneken and Sibylle Eigelshoven and Michael Steffens and Ant{\`o}nia Flaquer and Stefan Herms and Tim Becker and Anne-Katrin Kort{\"u}m and Dale R. Nyholt and Zhen Zhen Zhao and Grant W. Montgomery and Nicholas G. Martin and Thomas W. M{\"u}hleisen and Margrieta A Alblas and Susanne Moebus and Karl-Heinz J{\"o}ckel and Martina Broecker-Preuss and Raimund Erbel and R. Reinartz and Regina C Betz and Sven Cichon and P. Propping and Max P. Baur and Thomas F. Wienker and Roland Kruse and Markus M. N{\"o}then},
  journal={Nature Genetics},
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 × 10−15). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway. 

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The Wellcome Trust Case Control Consortium

Hillmer, A.M
Am. J. Hum. Genet • 2005

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