Susceptibility to vinblastine-induced aneuploidy and preferential chromosome segregation during meiosis I in Robertsonian heterozygous mice.

@article{Pacchierotti1995SusceptibilityTV,
  title={Susceptibility to vinblastine-induced aneuploidy and preferential chromosome segregation during meiosis I in Robertsonian heterozygous mice.},
  author={Francesca Pacchierotti and Cecilia Tiveron and John B. Mailhes and Muriel T. Davisson},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={1995},
  volume={15 5},
  pages={217-30}
}
Chromosome segregation at meiosis I was studied in oocytes and spermatocytes of four different Robertsonian (Rb) heterozygous mouse stocks by cytogenetic analysis of meiotic products. Two Rb heterozygotes spontaneously yielded high frequencies of unbalanced oocytes. In one case, Rb(2.18)Rma, the excess hyperploidy was mainly accounted for by nondisjunction of normal bivalents, suggesting a generalized impairment of meiotic segregation. In each stock, frequencies of hyperploid spermatocytes were… CONTINUE READING