Susceptibility to platelet-activating factor-induced airway hyperreactivity and hyperpermeability: interstrain variation and genetic control.

@article{Longphre1995SusceptibilityTP,
  title={Susceptibility to platelet-activating factor-induced airway hyperreactivity and hyperpermeability: interstrain variation and genetic control.},
  author={Malinda Longphre and Steven R. Kleeberger},
  journal={American journal of respiratory cell and molecular biology},
  year={1995},
  volume={13 5},
  pages={586-94}
}
Platelet-activating factor (PAF) is a proinflammatory mediator known to elicit changes in airway reactivity and vascular permeability, and it may also have a role in the development and progression of acute respiratory distress syndrome and asthma. We have developed a mouse model to test the hypothesis that these traits were controlled by a single gene and were mechanistically related. We further hypothesized that there was a relationship between PAF-induced hyperreactivity and baseline… CONTINUE READING

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