Corpus ID: 27963021

Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve.

@article{Huang1997SusceptibilityTL,
  title={Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve.},
  author={Jie Huang and Johann G. Thalhammer and Stephen A. Raymond and Gary R. Strichartz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={282 2},
  pages={
          802-11
        }
}
  • Jie Huang, Johann G. Thalhammer, +1 author Gary R. Strichartz
  • Published in
    The Journal of pharmacology…
    1997
  • Chemistry, Medicine
  • Mechanosensitive A beta-fibers (n = 29) and nociceptive A delta- (n = 6) and C-fibers (n = 10) of the rat sciatic nerve were superfused with lidocaine (LID, 0.1-1.4 mM) in vivo. The [LID] to abolish single electrically stimulated impulses (tonic blockade) in axons was 0.2 to 0.8 mM for A beta-, 0.1 to 0.6 mM for A delta- and 0.1 to 1.4 mM for C-fibers. Within each of the fiber groups there was no dependence of blocking [LID] on conduction velocity; slower fibers were no more susceptible than… CONTINUE READING

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    Citations

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    Kinetics of uptake and washout of lidocaine in rat sciatic nerve in vitro.

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    Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats.

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