Susceptibility to infections and in vitro immune functions in cartilage-hair hypoplasia

  title={Susceptibility to infections and in vitro immune functions in cartilage-hair hypoplasia},
  author={Outi M{\"a}kitie and Ilkka I Kaitila and Emma Merike Savilahti},
  journal={European Journal of Pediatrics},
Cartilage-hair hypoplasia (CHH), an autosomal recessive chondrodysplasia, results in severe growth failure, sparse hair and impaired cellular immunity. Lymphocyte subpopulations and proliferative responsiveness in mitogen stimulation were analysed in 35 patients of whom 31% had an increased incidence of infections the year prior to the evaluation. Of the patients, 57% had a decreased CD4+ cell count which led to a decreased total count of T-lymphocytes in 52% and a subnormal CD4+/CD8+ cell… CONTINUE READING


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