Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.

@article{Wiencke1993SusceptibilityTI,
  title={Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.},
  author={John K. Wiencke and Karl T. Kelsey},
  journal={IARC scientific publications},
  year={1993},
  volume={127},
  pages={265-73}
}
Occupational exposure to butadiene is associated with the occurrence of lymphohaematopoietic cancers. The mutagenicity of butadiene is thought to be mediated by its mono- and diepoxide metabolites, which are capable of binding to DNA. Diepoxybutane is the most potent genotoxic metabolite and is known to produce interstrand DNA cross-links. In order to study individual differences in response to the genotoxicity of diepoxybutane, we devised a human lymphocyte culture system that involves short… CONTINUE READING