Susceptibility to human papillomavirus-associated cervical intra-epithelial neoplasia is determined by specific HLA DR-DQ alleles.

@article{Odunsi1996SusceptibilityTH,
  title={Susceptibility to human papillomavirus-associated cervical intra-epithelial neoplasia is determined by specific HLA DR-DQ alleles.},
  author={Kunle O Odunsi and George Terry and Linda Ho and John Bell and Jack Cuzick and Trivadi Sundaram Ganesan},
  journal={International journal of cancer},
  year={1996},
  volume={67 5},
  pages={595-602}
}
Human papillomaviruses (HPV) play a causative role in the aetiology of cervical intra-epithelial neoplasia (CIN) and cervical cancer. Human leukocyte antigens (HLA) are important in the regulation of immune response to foreign antigens. The role of genetic variation at the HLA class II loci (DR and DQ) in CIN (HPV 16, 18, 31 and 33 typed) was investigated by PCR DNA amplification and oligonucleotide probe typing of cervical smears from British Caucasian patients (n = 176) and controls (n = 416… CONTINUE READING

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