Susceptibility to exacerbation in chronic obstructive pulmonary disease.


BACKGROUND Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete. In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity. METHODS We… (More)
DOI: 10.1056/NEJMoa0909883


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