Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

@article{Tudor2000SusceptibilityTD,
  title={Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels},
  author={G. Tudor and A. Ram{\'i}rez Aguilera and Douglas O Halverson and Nigel Laing and Edward A. Sausville},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={574-586}
}
To define the responses of apoptotic regulatory proteins to different chemotherapeutic agents, we investigated the expression of Bcl-2 family gene products, the release of cytochrome c, and the activation of pro-caspase-3 during apoptosis induced by Taxol and Thiotepa, in the MCF-7 breast carcinoma and the HL-60 leukemia cell lines. The earliest event induced by drug exposure was increase in Bad protein levels, followed by Bcl-2 down-regulation, cytochrome c release, and Bcl-xL and Bax up… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 66 references

- free extracts : requirement for dATP and cytochrome c

MH Cardone, N Roy, +5 authors JC Reed
1998

Similar Papers

Loading similar papers…