Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes.

@article{Loke2002SusceptibilityTD,
  title={Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes.},
  author={Hsin Loke and Delia Bethell and Cao Xuan Thanh Phuong and Nick Day and Nicholas White and Jeremy J. Farrar and A. Hill},
  journal={The American journal of tropical medicine and hygiene},
  year={2002},
  volume={67 1},
  pages={102-6}
}
Dengue is an increasingly important cause of morbidity and mortality in the tropics, with more than a billion people at risk each year. Immunologic enhancement is thought to contribute to disease pathogenesis. Only a very small proportion of infected individuals develop life-threatening dengue hemorrhagic fever (DHF). In a large case-control study with 400 DHF patients and 300 matched controls, we have assessed five polymorphic non-HLA host genetic factors that might influence susceptibility to… CONTINUE READING