Susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ α Arg 52 and HLA-DQ β non-Asp 57 alleles

@article{GutirrezLpez1992SusceptibilityTT,
  title={Susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ α Arg 52 and HLA-DQ β non-Asp 57 alleles},
  author={Mar{\'i}a Dolores Guti{\'e}rrez-L{\'o}pez and Suzanne Bertera and M. T. Chantres and C. Vavassori and JaniceS. Dorman and Massimio Trucco and Manuel Serrano-R{\'i}os},
  journal={Diabetologia},
  year={1992},
  volume={35},
  pages={583-588}
}
HLA-DQ α and β alleles were chosen as the most sensitive Type 1 (insulin-dependent) diabetes mellitus susceptibility markers for evaluating the disease associations and Type 1 diabetes risk in a population-based registry from Madrid. The absence of aspartic acid in position 57 of the DQ β chain (non-Asp 57), and the presence of arginine in position 52 of the DQ a chain (Arg 52) were found to be reliable markers of Type 1 diabetes susceptibility among the Spanish population, with significantly… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Increasing trend in Type i (insulin-dependent) diabetes mellitus in child- hood in Finland. Analysis of age, calendar time and birth cohort effects during 1965-1984

  • J Tuomilehto, M Rewers, A Reunanen
  • Diabetologia
  • 1991
3 Excerpts

Similar Papers

Loading similar papers…