Susceptibility to Childhood Acute Lymphoblastic Leukemia : Influence of CYP 1 A 1 , CYP 2 D 6 , GSTM 1 , and GSTT 1 Genetic Polymorphisms

@inproceedings{Krajinovic1999SusceptibilityTC,
  title={Susceptibility to Childhood Acute Lymphoblastic Leukemia : Influence of CYP 1 A 1 , CYP 2 D 6 , GSTM 1 , and GSTT 1 Genetic Polymorphisms},
  author={Maja Krajinovic and Damian Labuda and Chantal Richer and Sepideh Karimi and Daniel Sinnett},
  year={1999}
}
Although acute lymphoblastic leukemia (ALL) is the most common childhood cancer, factors governing susceptibility to this disease have not yet been identified. As such, ALL offers a useful opportunity to examine the glutathione S-transferase and cytochrome P450 genes in determining susceptibility to pediatric cancers. Both enzymes are involved in carcinogen metabolism and have been shown to influence the risk a variety of solid tumors in adults. To determine whether these genes played a similar… CONTINUE READING

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The Leukemias: Epidemiologic Aspects

MS Linet
1985
View 3 Excerpts
Highly Influenced

Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 1997

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