Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

@article{Tanaka2015SusceptibilityT6,
  title={Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.},
  author={Yoichi Tanaka and Motohiro Kato and Daisuke Hasegawa and Kevin Yuji Urayama and Hisaya Nakadate and Kensuke Kondoh and Kozue Nakamura and Katsuyoshi Koh and Takako Komiyama and Atsushi Manabe},
  journal={British journal of haematology},
  year={2015},
  volume={171 1},
  pages={109-15}
}
Genotyping of TPMT prior to 6-mercaptopurine (6-MP) administration in acute lymphoblastic leukaemia (ALL) patients has been integrated into clinical practice in some populations of European ancestry. However, the comparable rates of 6-MP myelotoxicity, but rarity of TPMT variants, in Asians suggest that major determinants have yet to be discovered in this population. We genotyped 92 Japanese paediatric ALL patients for NUDT15 rs116855232, a 6-MP toxicity-related locus discovered in Asians… CONTINUE READING

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The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6 - mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children

  • Y. Tanaka, A. Manabe, +6 authors T. Komiyama
  • Leukemia Research
  • 2012
Highly Influential
4 Excerpts

Methotrexate / 6 - mercaptopu - rine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia : results from the NOPHO ALL - 92 study

  • W. D. Ludwig, G. Henze, H. Gadner
  • Blood
  • 2009

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