Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions.

@article{Maurer2015SusceptibilityPO,
  title={Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions.},
  author={Elisabeth Maurer and Ulrike Binder and Manuela Sparber and Michaela Lackner and Rita D F Caramalho and Cornelia Lass-Fl{\"o}rl},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 2},
  pages={1344-6}
}
The effect of hypoxic conditions on the in vitro efficacy of amphotericin B and posaconazole against Mucorales was evaluated by defining MICs with Etest and broth microdilution and identifying minimal fungicidal concentrations (MFCs). With Etest, oxygen-dependent changes were detected, while the MIC and the MFC determined with broth microdilution remained unaltered with reduced oxygen levels. The observed differences depended on the method used. 
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