Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.

@article{Bossers2000SusceptibilityOS,
  title={Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.},
  author={Alex Bossers and Ruth de Vries and Mari A. Smits},
  journal={Journal of virology},
  year={2000},
  volume={74 3},
  pages={1407-14}
}
Polymorphisms in the prion protein (PrP) gene are associated with phenotypic expression differences of transmissible spongiform encephalopathies in animals and humans. In sheep, at least 10 different mutually exclusive polymorphisms are present in PrP. In this study, we determined the efficiency of the in vitro formation of protease-resistant PrP of nine sheep PrP allelic variants in order to gauge the relative susceptibility of sheep for scrapie. No detectable spontaneous protease-resistant… CONTINUE READING

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