Susceptibility of recombinant porcine endogenous retrovirus reverse transcriptase to nucleoside and non-nucleoside inhibitors

@article{Wilhelm2002SusceptibilityOR,
  title={Susceptibility of recombinant porcine endogenous retrovirus reverse transcriptase to nucleoside and non-nucleoside inhibitors},
  author={M. L. Wilhelm and Jay A Fishman and Ren{\'e}e Pontikis and A.-M. Aubertin and F. X. Wilhelm},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2002},
  volume={59},
  pages={2184-2190}
}
Transplantation of organs, tissues or cells from pigs to humans could be a potential solution to the shortage of human organs for transplantation. Porcine endogenous retroviruses (PERVs) remain a major safety concern for porcine xenotransplantation. Thus, finding drugs that could be used as virological prophylaxis (or therapy) against PERV replication would be desirable. One of the most effective ways to block retroviral multiplication is to inhibit the enzyme reverse transcriptase (RT) which… CONTINUE READING

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