Susceptibility of irradiated mice to Bacillus anthracis sterne by the intratracheal route of infection.

@article{Brook2001SusceptibilityOI,
  title={Susceptibility of irradiated mice to Bacillus anthracis sterne by the intratracheal route of infection.},
  author={Itzhak Brook and Thomas B. Elliott and Rita A Harding and S Samy Bouhaouala and Sharon J Peacock and G. David Ledney and Gregory B. Knudson},
  journal={Journal of medical microbiology},
  year={2001},
  volume={50 8},
  pages={702-11}
}
The susceptibility of sublethally irradiated mice to pulmonary infection with Bacillus anthracis was investigated in a mouse model. Female B6D2F1/J mice were challenged intratracheally with 4.3 x 10(6), 3.7 x 10(7) and 4.4 x 10(8) cfu of B. anthracis Sterne spores 4 days after 60Co gamma-radiation at a dose of 0, 1, 2, 3, 4, 5, 6 or 7 Gy. Bacterial cultures were obtained from lung, spleen homogenates and heart blood. A biphasic mode of mortality was observed, with a constant response of up to 3… CONTINUE READING

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