Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor.

@article{Fleiszig1998SusceptibilityOE,
  title={Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor.},
  author={Suzanne M. J. Fleiszig and Vicky Vallas and Chin Hee Jun and Leo Mok and Daniel F. Balkovetz and Michael Garrett Roth and Keith E. Mostov},
  journal={Infection and immunity},
  year={1998},
  volume={66 7},
  pages={
          3443-6
        }
}
Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the… CONTINUE READING

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Pseudo - monas aeruginosa - mediated cytotoxicity and invasion correlate to distinct genotypes at the loci encoding exoenzyme S

S. M. J. Fleiszig, H. Miyazaki J. P. Wiener-Kronish, +5 authors D. W. Frank
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