Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development

@article{Mcdonald1992SusceptibilityOB,
  title={Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development},
  author={John W. Mcdonald and William H. Trescher and Michael V Johnston},
  journal={Brain Research},
  year={1992},
  volume={583},
  pages={54-70}
}
The excitatory and excitotoxic actions of the endogenous excitatory amino acid (EAA) neurotransmitter, glutamate, are mediated by activation of three common subtypes of EAA receptors: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/quisqualate and kainate receptors. EAA neurotransmitter systems play a number of physiological roles in the regulation and organization of neural systems during development. However, excessive activation of this… CONTINUE READING

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