Susceptibility of Sigmodon hispidus

  title={Susceptibility of Sigmodon hispidus},
  author={Krishnan Kolappaswamy},
  journal={Lab Animal},
taxonomy PHYLUM: Chordata CLass: Mammalia Order: rodentia FaMiLY: Cricetidae research résumé Cotton rats serve as excellent, alternative models for pathogens that do not infect conventional rat and mouse models1. Wild cotton rats were used in polio research in 1937. After World War II, they were used in development of the typhus vaccine and in dental caries research. Cotton rats have been used to model many different respiratory infections and their associated immunogenicity2,3. These include… 
2 Citations

Passive narcosis for anesthesia induction in cotton rats (Sigmodon hispidus)

This work describes a method of isoflurane anesthesia induction in the home cage that reduces the risk of animal escape, minimizes stress during induction, and provides additional safety for staff, and uses a minimal amount of inhalant anesthetic.



Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus).

A review of the cotton rat model as a model for infection with other respiratory viral pathogens including influenza and rhinovirus and their potential contribution to the development of new therapies is focused on.

Diversifying animal models: the use of hispid cotton rats (Sigmodon hispidus) in infectious diseases

Through the development of new reagents, the hispid Cotton rat can be used to study immune responses against the respective pathogen and facilitate the use of hispid cotton rats as animal models in the pathogenesis of infectious diseases.

Current animal models: cotton rat animal model.

  • S. Niewiesk
  • Biology
    Current topics in microbiology and immunology
  • 2009
The cotton rat (Sigmodon hispidus) model has proven to be a suitable small animal model for measles virus pathogenesis to fill the niche between tissue culture and studies in macaques and promises to beA useful model for the study of polymicrobial disease (interaction between measles virus and secondary pathogens).

The cotton rat model of respiratory viral infections.

The cotton rat: an underutilized animal model for human infectious diseases can now be exploited using specific reagents to cytokines, chemokines, and interferons.

The cloning of 24 cotton rat genes encoding various cytokines, chemokines, and interferons will provide the tools for molecular analysis of pathogenesis and immune responses to a wide variety of pathogens and set the basis for the development of new prophylactic and therapeutic strategies against human infectious diseases.

The pathogenesis of respiratory syncytial virus infection in cotton rats.

Unlike the previously described response of experimentally infected infant ferrets, cotton rats are uniformly susceptible to pulmonary infection throughout life, thereby offering a model for long-term pulmonary studies heretofore not available.

Cotton Rat

The Cotton Rat as a Model for Staphylococcus aureus nasal colonization in humans: cotton rat S. aureus nasal colonization model.

  • J. Kokai-Kun
  • Biology, Medicine
    Methods in molecular biology
  • 2008
The cotton rat model is an excellent animal model to allow for the evaluation of the efficacy of various therapies, including semi-solid formulations, for determination of their ability to eradicate S. aureus nasal colonization.