• DOI:10.1038/laban.767
• Corpus ID: 36875974

Susceptibility of Sigmodon hispidus

@article{Kolappaswamy2015SusceptibilityOS,
  title={Susceptibility of Sigmodon hispidus},
  author={Krishnan Kolappaswamy},
  journal={Lab Animal},
  year={2015},
  volume={44},
  pages={199-199}
}

• K. Kolappaswamy
• Published 19 May 2015
• Biology
• Lab Animal

taxonomy PHYLUM: Chordata CLass: Mammalia Order: rodentia FaMiLY: Cricetidae research résumé Cotton rats serve as excellent, alternative models for pathogens that do not infect conventional rat and mouse models1. Wild cotton rats were used in polio research in 1937. After World War II, they were used in development of the typhus vaccine and in dental caries research. Cotton rats have been used to model many different respiratory infections and their associated immunogenicity2,3. These include measles3,4, adenovirus3,5, respiratory syncytial virus3,6,7, human influenza virus3,6,8, metapneumovirus3,6, human rhinovirus3, parainfluenza virus2,3, tuberculosis9 and nasal colonization of Staphylococcus aureus8,10. Cotton rats have also been used in studies of herpes simplex virus, Venezuelan equine encephalitis and human immunodeficiency virus2. In addition to bacterial and viral infections, cotton rats have been used to study fungi such as Microsporum and Trichophyton and parasites including Brugia , Coccidia, Dipetalonema, Echinococcus, Fasciola, Leishmania and Litomosoides2. Cotton rat cell lines and reagents, such as monoclonal antibodies and cytokines, are now available to facilitate studies of vaccine and antiviral therapies2,11.