Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF.

@article{Million1999SusceptibilityOL,
  title={Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF.},
  author={Mulugeta Million and Yvette F. Tach{\'e} and Peter A Anton},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={276 4},
  pages={G1027-G1036}
}
We assessed the role of central corticotropin-releasing factor (CRF) in stress-induced worsening of colitis in inbred rat strains with hypo (Lewis/N) and hyper (Fischer344/N) CRF responses to stress. Intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (TNB) induced colitis of similar severity in both strains as assessed on day 7 by macroscopic scoring, histological evaluation, tissue myeloperoxidase (MPO) activity, and decrease in food intake and body weight. Colitis was inhibited… CONTINUE READING

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