Susceptibility locus for Alzheimer's disease on chromosome 10.

@article{Myers2000SusceptibilityLF,
  title={Susceptibility locus for Alzheimer's disease on chromosome 10.},
  author={Amanda J. Myers and Peter Holmans and Heather Marshall and Jeong Seung Kwon and Denise Meyer and Dzanan Ramic and Shantia Shears and J. Booth and Fabienne Wavrant DeVri{\'e}ze and Richard C. Crook and Marian L. Hamshere and Richard D. Abraham and Nigel Tunstall and Feng Rice and S Carty and S Lillystone and Pat Kehoe and Varuni Rudrasingham and L Jones and Simon Lovestone and Jordi P{\'e}rez-Tur and Julie Williams and Michael J Owen and John S. Hardy and Alison M. Goate},
  journal={Science},
  year={2000},
  volume={290 5500},
  pages={
          2304-5
        }
}
The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm… CONTINUE READING

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